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KMID : 0350519920450041295
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Journal of Catholic Medical College
1992 Volume.45 No. 4 p.1295 ~ p.1305
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The Effect of Decompression with and without Naloxone Treatment on the Experimental Acute Caude Equina Syndrome in Cats
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Abstract
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This study observed neurological recovery after decompression with and without opiate antagonist naloxone, post-decompression treatment on the experimental cauda equina syndrome in cats, to investigate effective treatment for the syndrome mostly
caused
by rupture of intervetebral disc. Neurologic analysis using modified Tarlov grading scale and somatosensory evoked potential(SSEP) was performed on the 1, 2, 4, 7 and 14 days after treatment and microscopic examination of the cauda equina was
performed
on the 14 days after treatment.
Thirty three cats were divided into three group; control group(n=3),simple decompression(SD) group(n=15),and decompression with naloxone treated(DN) group(n=15). In the control group, only simple laminectomy was performed at the level of L6-7. In
SD
group, the cauda equina was epidurally constricted with nylon silk after laminectomy. In DN group, naloxone(1 mg/kg) was intraperitoneally injected after decompression. Both SD and DN groups were subdivided into five experimental groups,
according
to
the duration of cauda equina compression; 0.5 hour (0.5-SD and 0.5-DN), 1 hour(1-SD and 1-DN), 3 hours(3-SD and 3-DN), 6 hours(6-SD and 6-DN), and 24 hours(24-SD and 24-DN). Each subgroup consists of three cats.
@ES The results were as follows;
@EN 1) Neurolgical improvement was noted in groups 0.5-SD, 1-SD, 0.5-DN, 1-DN, and 3-DN, However, it was more significant in DNs than in SDs, especially in receiving early decompression including 0.5-DN and 1-DN.
2) The change of amplitude on SSEP was increased in each group. In DNs receiving early decompression, there was a marked increase of amplitude, which correlates very well with neurological recovery.
3) Histological examination of the cauda equina revealed epidural and peridural fibrosis with mild degree of chronic inflammation, Wallerian degeneration, axonal dystrophy and increased number of Schwann cells. However, there were no changes in
the
light microscopic findings among the experiemental groups.
In conclusion, our results indicate the importance of early decompression and naloxone treatment for the best recovery from acute cauda equina syndrome.
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KEYWORD
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